Haregewein Assefa, PhD, RPh

Associate Professor, Pharmaceutical and Biomedical Sciences

Hareg Assefa 2
  • Office: 230 West 125th Street, Room 430, New York 10027
  • Campus:
    Touro College of Pharmacy
  • Phone:
    (646)-981-4743
  • Email:
    haregewein.assefa@touro.edu

Education

Postdoctoral Fellow, University of Tennessee, College of Pharmacy; 1999-2002
PhD, University of Mississippi; 1999
B.Pharm, Addis Ababa University, Ethiopia; 1984  

Academic and Professional Honors

Professor of the Year, Touro College of Pharmacy, 2015
Nobles-Sam Graduate Research Award, Department of Medicinal Chemistry, University of Mississippi, 1997-1998
The American Chemical Society (ACS) Travel award, 1998
UNDP Graduate Fellowship, August 1993-May 1995
Awarded a medal for securing the top rank in B.Pharmacy, 1984

Professional Service

Accreditation Council for Pharmacy Education (ACPE) Site Evaluator

Peer Reviewer of Dove Medical Press Journals:

  • Drug Design, Development and Therapy
  • Infection and Drug Resistance
  • Journal of Multidisciplinary Healthcare
  • Research and Reports in Medicinal Chemistry 

Service to the College:

  • Chair- Admissions and Recruitment Committee 09/14 – present
  • Member of the Admissions and Recruitment Committee August 2010 – present
  • Member of the Promotion Committee – 01/2015 –present
  • Member of 2012 Commencement Award Committee
  • Member of 2013 teacher of the year selection committee 
  • Member of Standing Committee on Academic Integrity
  • Member of Ad Hoc Committee-Reflections/Grand Rounds Integration, Spring 2013

 

Teaching responsibilities

  • PHRM 502: Foundations of the Biomedical Sciences I: Immunology, Virology, Infectious Disease and Medicinal Chemistry
  • PHRM 508: Foundations of the Biomedical Science II: Pharmacology, Medicinal Chemistry and Therapeutics
  • PHRM 632: Principles of Clinical Sciences: Pharmacotherapeutics I
  • PHRM 637: Principles of Clinical Sciences: Pharmacotherapeutics II
  • PHRM 715: Drug Discovery and Developement Elective
  • PHRM 828: Grand Rounds I
  • PHRM 834: Grand Rounds II

Publications

Peer-reviewed publications

  • Maureen Sullivan, Tiffany Murray and Haregewein Assefa*. Women with Methylenetetrahydrofolate Reductase Gene Polymorphism and the Need for Proper Periconceptional Folate Supplementation. Journal of Pharmacy and Pharmacology. 2015, 3, 204-222.
  • Haregewein Assefa. Ebola Virus Potential Drug Targets and Prospects for Small Molecule Drug Discovery. J. Pharm. Sci. Pharmacol. 2014, 1, 313-321 
  • In Vitro and In Vivo Antimalarial Efficacy of Optimized Tetracyclines. Michael P. Draper; Beena Bhatia; Haregewein Assefa; Laura Honeyman; Lynne K. Garrity-Ryan; Atul K. Verma; Jiri Gut; Kelley Larson; Janice Donatelli; Ann Macone; Kevin Klausner; Raina G. Leahy; Aleksandrs Odinecs; Kwasi Ohemeng; Philip J. Rosenthal; Mark L. Nelsona. Antimicrobial Agents and Chemotherapy201357,  3131-3136
  • Isaac O. Donkor; Assefa, Haregewein; Liu, JiuyuStructural Basis for the Potent Calpain Inhibitory Activity of Peptidyl a-Ketoacids.  J. Med. Chem200851, 4346-4350.
  • Kuo, C-L; Assefa, H; Kamath, S; Brzozowski, Z; Slawinski, J; Saczewski, F; Buolamwini, J. K.; Neamati, N.  Application of CoMFA and CoMSIA 3D-QSAR and Docking Studies in Optimization of Mercaptobenzenesulfonamides as HIV-1 Integrase Inhibitors.    J.  Med. Chem200447, 385-99
  • Assefa, H;Kamath, S; Buolamwini, J. K. 3D-QSAR and Docking Studies on 4-      Anilinoquinazoline and 4-Anilinoquinoline Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitors. J. Comput.-Aided Mol. Design200317, 475-493
  • Buolamwini, J. K.; Assefa, H. Overview of Novel Anticancer Drug Targets. Methods in Molecular Medicine (2003), 85 (Novel Anticancer Drug Protocols), 3-28
  • Donkor, I. O.; Assefa, H.; Rattendi, D.; Lane, S.; Vargas, M.; Goldberg, B.; Bacchi, C. Trypanocidal Activity of Dicationic Compounds Related to Pentamidine. Eur. J. Med. Chem. 200136, 531-538.
  • Assefa, H.; Nimrod, A.; Walker, L.; Sindelar, R. Synthesis and Evaluation of Potential Complement Inhibitory Semi-Synthetic Analogs of Oleanolic Acid. Bioorg. Med. Chem. Lett19999, 1889-1894
  • Buolamwini, J. K.; Assefa, H. CoMFA and CoMSIA 3D-QSAR and Docking Studies on Conformationally-Restrained Cinnamoyl HIV-1 Integrase Inhibitors: Exploration of a Binding Mode at the Active Site. J. Med. Chem. 200245, 841-852.
  • Assefa, H.; Nimrod, A.; Walker, L.; Sindelar, R. Enantioselective Synthesis and Complement Inhibitory Assay of A/B-Ring Partial Analogs of Oleanolic Acid.  Bioorg. Med. Chem. Lett200111, 1619-1623
  • Hicks, S.; Assefa, H.; Sindelar, R. Computer-Aided Design of Enzyme Inhibitors: Recent Studies. Current Opinion in Drug Discovery and Development19981, 223-234.

Patents

  • Substituted tetracycline compounds for treatment of inflammatory skin disorders.      Assefa, Haregewein; Bhatia, Beena; Draper, Michael; Honeyman, Laura; Molnar, Dennis P.  (Paratek Pharmaceuticals, Inc., USA; Oak, K., Kim).    PCT Int. Appl.  (2008) 101pp.  CODEN: PIXXD2  WO  2008079363  A2  20080703
  • Substituted tetracycline compounds for treatment of bacterial infections and neoplasms.      Abato, Paul; Assefa, Haregewein; Berniac, Joel; Bhatia, Beena; Bowser, Todd; Grier, Mark; Honeyman, Laura; Ismail, Mohamed; Kim, Oak K.; Nelson, Mark; Pan, Jingwen; Verma, Atul.  (Paratek Pharmaceuticals, Inc., USA).    PCT Int. Appl.  (2008),     224pp.  CODEN: PIXXD2  WO  2008079339  A2  20080703 
  • Preparation of 10-substituted tetracycline compounds as antibiotics.      Abato, Paul; Assefa, Haregewein; Berniac, Joel; Bowser, Todd; Chen, Jackson; Grier, Mark; Honeyman, Laura.  (Paratek Pharmaceuticals, Inc., USA).    PCT Int. Appl.  (2007),     96pp.  CODEN: PIXXD2  WO  2007014154  A2  20070201
  • Preparation of substituted tetracycline compounds for the treatment of bacterial infections and neoplasms.      Abato, Paul; Assefa, Haregewein; Berniac, Joel; Bhatia, Beena; Bowser, Todd; Chen, Jackson; Grier, Mark; Honeyman, Laura; Ismail, Mohamed Y.; Nelson, Mark; Kwasi, Ohemeng; Pan, Jingwen.  (Paratek Pharmaceuticals, Inc., USA).    PCT Int. Appl.  (2006),     126 pp.  CODEN: PIXXD2  WO  2006047756  A2  20060504
  • Prodrugs of 9-aminomethyltetracycline compounds.   Amoo, Victor; Assefa, Haregewein; Bhatia, Beena; Berniac, Joel; Bowser, Todd; Chen, Jackson; Grier, Mark; Honeyman, Laura; Kim, Oak K.; Mechiche, Rachid; Ohemeng, Kwasi; Pan, Jingwen.   U.S. Pat. Appl. Publ.  (2006),     34pp., Cont.-in-part of U.S. Ser. No. 877,454.  CODEN: USXXCO  US  2006287283  A1  20061221  CAN 146:62519  AN 2006:1339348 
  • Preparation of prodrugs of 9-aminomethyl tetracycline compounds.     Ohemeng, Kwasi; Amoo, Victor; Kim, Oak; Bowser, Todd; Assefa, Haregewein; Bhatia, Beena; Berniac, Joel; Chen, Jackson; Grier, Mark; Honeyman, Laura; Pan, Jingwen; Mechiche, Rachid.  (Paratek Pharmaceuticals, Inc., USA).    PCT Int. Appl.  (2005), 45 pp.  CODEN: PIXXD2  WO  2005009944  A1  20050203
  • Preparation of substituted tetracycline analogs for use in antibiotic pharmaceutical compositions.     Nelson, Mark L.; Ohemeng, Kwasi; Amoo, Victor; Kim, Oak; Abato, Paul; Assefa, Haregewein; Berniac, Joel; Bhatia, Beena; Bowser, Todd; Chen, Jackson; Grier, Mark; Hohos, Aaron; Honeyman, Laura; Ismail, Mohamed Y.; Mechiche, Rachid; Nihlawi, Mohammed; Sizensky, Emmanuelle.  (Paratek Pharmaceuticals, Inc., USA).    PCT Int. Appl.  (2005), 81 pp.  CODEN: PIXXD2  WO  2005009943  A2  20050203
  • Preparation of substituted tetracycline compounds for the treatment of bacterial infections and neoplasms.     Nelson, Mark L.; Ohemeng, Kwasi; Frechette, Roger; Abato, Paul; Assefa, Haregewein; Bandarage, Upul; Berniac, Joel; Bhatia, Beena; Chen, Jackson; Ismail, Mohamed Y.; Kim, Oak A.; Mathews, Jude; McIntyre, Laura; Nihlawi, Mohammed; Pearson, Andre; Reddy, Laxma; Sheahan, Paul; Sizensky, Emmanuelle; Tourigny, Justin; Verma, Atul K.; Viski, Peter; Warchol, Tadeusz.  (Paratek Pharmaceuticals, Inc., USA).    PCT Int. Appl.  (2003), 118 pp.  CODEN: PIXXD2  WO  2003079984  A2  20031002       

Presentations

  • T. Murray; M. Sullivan; H. Assefa and C. Kim. The effect of Methylenetetrahydrofolate reductase (MTHFR) Polymorphisms on Maternal Folic Acid Metabolism and Its Association with Congenital Diseases. American Pharmacists Association (APhA) Annual Meeting & Exposition, March 27-30, 2015, in San Diego, CA.
  • M. Rumore; H. Assefa; P. Basu; P. Kumar and Y. Patel. Analysis of MedWatch Alerts 2009-2014. American Pharmacists Association (APhA) Annual Meeting & Exposition, March 27-30, 2015, in San Diego, CA.
  • Shinkazh Nataliya, Veltri Keith, Patel Shreya , Assefa Haregewein W., Akhavein Nima, Moore Ronnie, Georgeta Vaidean Georgeta. Grand Rounds as a Longitudinal Course for Synthesis and Integration of Didactic and Experiential EducationAmerican Association of Colleges of Pharmacy. Chicago, IL July 2013
  • Buolamwini, J. K.; Assefa, H. CoMFA and CoMSIA 3D-QSAR Studies of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors. 221st ACS National Meeting, San Diego, CA, U. S. A., April 1-5, 2001.
  • Assefa, H.; Donkor, I. Synthesis and Calpain Inhibitory Activity of a-Keto Ester and a-Keto Acid Tripeptides with Varying Lipophilic Groups at the P3 Position. 221st ACS National Meeting, San Diego, CA, U. S. A., April 1-5, 2001.
  • Assefa, H.; Nimrod, A.; Walker, L.; Sindelar, R. Design, Synthesis and Evaluation of Semi-Synthetic and Partial analogs of Oleanolic Acid as Potential Complement Inhibitors. 216th ACS National Meeting, Boston, MA, U. S. A., August 23-27, 1998.
  • Sindelar, R. D.; Srivastava, R.P.; Bartyzel, P.; Assefa, H.; Walker, L. A; Zhu, X.; Marsh, H. C. Jr.; Scesney, S. M. The Design, Synthesis and Evaluation of Potential Human Complement Inhibitors Based on a Natural Product Model. 214th ACS National Meeting, Las Vegas, NV, U. S. A., September 7-11, 1997.
  • Sindelar, R. D.; Srivastava, R. P.; Bartyzel, P.; Assefa, H.; Walker, L. A.; Zhu, X; Marsh, H. C. Jr.; Scesney, S. M. The Complement Cascade-A Medicinal Chemist’s Target for Immune Modulation. 47th Southeast/51st Southwest Joint ACS Regional Meeting, Memphis, TN, U. S. A. November 29-December 1, 1995.
  • Mary Acheampong, Kavita Bhikhi, Daviana Dueño, Bobby Glover, Lachoy Harris, Alafia Henry, Randol Mata, Marisa VanBrakle, Thijs Beuming, Haregewein Assefa, and Allison Granberry. A Physical Model of Beta-2 Adrenergic Receptor. American Society for Biochemistry and Molecular Biology Annual Meeting, Wshington, D.C., United States, April 9-11, 2011 (The FASEB Journal, 25, Meeting Abstracts; April, 2011: lb155)
  • Bhatia, Beena; Assefa, Haregewein; Honeyman, Laura; Verma, Atul; Draper, Michael; Rosenthal, Phillip; Gut, Jiri; Garrity-Ryan, Lynn; Nelson, Mark L. Synthesis and biological activity of novel and potent C7 sancycline derivatives against Plasmodium falciparum. Paratek Pharmaceuticals, Inc, Boston, MA, USA.    Abstracts of Papers, 234th ACS National Meeting, Boston, MA, United States, August 19-23, 2007.
  • Nelson, Mark L.; Honeyman, Laura; Ismail, Mohamed; Bhatia, Beena; Verma, Atul K.; Warchol, Tadeusz; Bowser, Todd; Berniac, Joel; Mechiche, Rachid; Abato, Paul; Assefa, Haregewein.Synthesis of diverse tetracycline derivatives via Pd-catalyzed reactions: Creation of a large collection of novel 3rd generation tetracyclines.  Paratek Pharmaceuticals, Inc, Boston,  MA,  USA.    Abstracts of Papers, 231st ACS National Meeting, Atlanta, GA, United States, March 26-30, 2006
  • Buolamwini, J. K.; Addo, J. K.; Zhang, Y; Assefa, H.  Design, synthesis and binding affinity of bifunctional chemoaffinity and photoaffinity probes for the es nucleoside transporter.    223rd ACS National Meeting, Orlando, FL, U. S. A., April 7-11, 2002.
  • Assefa, H; Donkor, I. O.  “Synthesis and calpain inhibitory activity of alpha-ketoester and alpha-ketoacid tripeptides with varying lipophilic groups at the P3 position. 27th Annual MALTO Medicinal Chemistry and Pharmacognosy Meeting. New Orleans, LA, U. S. A. May 21-23, 2000.
  • Assefa, H; Nimrod, A; Walker, L; Sindelar, R. Synthesis and Evaluation of Semi-synthetic Analogs of Oleanolic Acid as Potential Complement Inhibitors.25th Annual MALTO Medicinal chemistry and Pharmacognosy Meeting, Monroe, LA., U. S. A. May 17-19, 1998.
  • Assefa, H; Robert D. Sindelar. Design and Synthesis of D/E-Ring Partial Analogs of Oleanolic Acid as Potential Complement Inhibitors. 24th Annual MALTO Meeting, Little Rock, AR, U. S. A., May 18-20, 1997.