The Effect of Antibiotic Treatment and the Role of Efflux Transporters on Resistance in Pseudomonas aeruginosa Biofilms

Zara Imtiaz, along with co-authors Dr. Paramita Basu, Avinash Chatoo, and Will Wang presented a study that tested the ability of three commonly used antibiotics to inhibit biofilm growth. The study also examined gene expression levels before and after antibiotic treatment, and how efflux transporters expel antibiotics. As the pathogen Pseudomonas a(PA) becomes more antibiotic-resistant, it’s important to discover new ways to respond. The study showed that the antibiotics Ofloxacin (OFLX), Tobramycin (TOB), and Ceftazidime (CAZ) have shown less resistance to PA. OFLX was more effective at lower concentrations, while TOB was most effective at higher concentrations.